Anti-CHRM2

Anti-CHRM2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R30388 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The muscarinic acetylcholine receptor M2,... more
Product information "Anti-CHRM2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor. The M2 muscarinic receptors are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system, by slowing the speed of depolarization. The CHRM2 gene inhibits the release of acetylcholine from cholinergic fibers in the lungs and elsewhere. In airway parasympathetic neurons, it is decreased by viral infections and by interferon-gamma, increasing actylcholine release. This gene is though to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing. In a sample of 667 individuals from 304 families, Gosso MF et al. genotyped three single-nucleotide polymorphisms(SNPs) in the CHRM2 gene on 7q31-35. The protein is implicated in memory and cognition, and its function is impaired in many neuropsychiatric disorders. Wang et al. cited evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 gene with alcohol dependence and major depressive syndrome. Protein function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3), this then triggers calcium ion release into the cytosol. [The UniProt Consortium]
Keywords: Anti-CHRM2, Anti-Muscarinic acetylcholine receptor M2, CHRM2 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: R30388

Properties

Application: WB, IHC (paraffin)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: An amino acid sequence from the C-terminus of human CHRM2 (EKQNIVARKIVKMTK) was used as the immunogen for this CHRM2 antibody (100% homologous human, mouse and rat).
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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