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![Anti-Chitotriosidase (Chitinase 1, CHIT-1)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C4164-50.100 | 100 µg | - | - |
3 - 19 business days* |
916.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human CHIT-1 (chitotriosidase-1, also chitinase-1) is a 50kD, secreted glycoprotein that belongs... more
Product information "Anti-Chitotriosidase (Chitinase 1, CHIT-1)"
Human CHIT-1 (chitotriosidase-1, also chitinase-1) is a 50kD, secreted glycoprotein that belongs to glycosylhydrolase family #18. It is synthesized by macrophages, and may serve to degrade chitin (poly-N-acetylglucosamine)-containing pathogens such as fungi and nematodes. Mature CHIT-1 is 435 amino acids (aa) in length, and contains a catalytic domain (aa22-372) followed by a chitin-binding region (aa373-466). Very high levels of CHIT1 are found in the plasma of patients with Gaucher's disease type I. Mature human CHIT-1 is 79% aa identical to mouse CHIT-1. Applications: Suitable for use in Direct ELISA, Immunoprecipitation and Neutralization. Other applications not tested. Recommended Dilutions: ELISA (Direct): 0.5-1.0ug/ml. Detection limit for rhCHIT1 is approximately 2ng/well., Immunoprecipitation: 25ug/ml to immunoprecipitate rhCHIT1 from conditioned cell culture medium. , Neutralization: The antibody was preincubated with the enzyme at different molar ratios at RT for 30 min. The enzyme was then assayed with 4-MU-beta-D-N,N',N''-triacetylchitotriose. 50% of the enzymatic activity was inhibited by the antibody at approximately 56ng/ml (IC 50) under conditions in which the enzyme was present at 20ng/ml and the substrate concentration was 0.01mM. IC 50 was achieved at approximately 1:1 molar ratio of the antibody to the enzyme., Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-CHIT1, EC=3.2.1.14, Anti-Chitinase-1, Anti-Chitotriosidase-1 |
Supplier: | United States Biological |
Supplier-Nr: | C4164-50 |
Properties
Application: | ELISA, IP, Neutr. |
Antibody Type: | Monoclonal |
Clone: | 7H206 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | NS0-derived rhCHIT-1 |
Format: | Affinity Purified |
Database Information
KEGG ID : | K01183 | Matching products |
UniProt ID : | Q13231 | Matching products |
Gene ID | GeneID 1118 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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