Anti-CGRP (Clone 4901)

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. It exists in two major forms that share greater than 90% sequence homology, alpha-CGRP that is produced by alternative RNA splicing of the calcitonin gene CALCI and beta-CGRP that is encoded by CALCII in humans. CGRP is primarily expressed in A and Cdelta fibers and exhibits perivascular localization but is also expressed in keratinocytes and endothelial progenitor cells. CGRP binds to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) and has roles in efferent function, nociception, and vasodilation. Levels of CGRP are increased in various pain states, including migraine. It also suppresses TNF-alpha, increases fibroblast motility and extracellular matrix synthesis, and induces Schwann cell proliferation to facilitate peripheral nerve regeneration following injury. Cayman's CGRP Monoclonal Antibody (Clone 4901) can be used for ICC applications.Synonyms: Calcitonin Gene-Related Peptide. Immunogen: Rat alpha-CGRP. Source: 10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol. Clone Designation: 4901. Formulation: (Request formulation change), 100 µl of protein G-purified mouse monoclonal antibody. Host: Mouse. Isotype: IgG2a. Applications: ICC.