Anti-CDK4, clone SQab1865

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Discount	Price
ARG66317.50	50 µl		-	-	6 - 14 business days*		30 %	436.00€ 305.20€
ARG66317.100	100 µl		-	-	6 - 14 business days*		30 %	624.00€ 436.80€

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Protein function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and... more

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Product information "Anti-CDK4, clone SQab1865"

Protein function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. [The UniProt Consortium]

Keywords:	Anti-CDK4, Anti-PSK-J3, EC=2.7.11.22, Anti-Cyclin-dependent kinase 4, Anti-Cell division protein kinase 4
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG66317

Properties

Application:	WB
Antibody Type:	Monoclonal
Clone:	SQab1865
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, african green monkey, bovine, dog, swine
Immunogen:	Synthetic peptide around the N-terminus of CDK4
MW:	34 kD
Format:	Purified