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![Anti-CD8A (Cytotoxic- & Suppressor T-Cell Marker)(Clone: C8/468)](https://www.biomol.com/media/image/99/7d/d0/ABE-36-1873-100_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-36-1873-100 | 100 µg | - |
3 - 11 business days* |
853.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8... more
Product information "Anti-CD8A (Cytotoxic- & Suppressor T-Cell Marker)(Clone: C8/468)"
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha / beta ) or as a homodimer (CD8 alpha / alpha ). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. Protein function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK- cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. [The UniProt Consortium]
Keywords: | Anti-MAL, Anti-CD8A, Anti-CD8a, Anti-T-cell surface glycoprotein CD8 alpha chain, Anti-T-lymphocyte differentiation antigen T8/Leu-2, Monoclonal Antibody to CD8A (Cytotoxic- & Suppressor T-Cell Marker)(Clone: C8/468) |
Supplier: | Abeomics |
Supplier-Nr: | 36-1873 |
Properties
Application: | FC, IF, IHC |
Antibody Type: | Monoclonal |
Clone: | C8/468 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Human CD8 recombinant protein |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06458 | Matching products |
UniProt ID : | P01732 | Matching products |
Gene ID | GeneID 925 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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