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![Anti-CD8a Cocktail, clone C8/468 + C8/144B](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V3134SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in sterile PBS, BSA free, sodium azide free. CD8 is a cell surface receptor expressed... more
Product information "Anti-CD8a Cocktail, clone C8/468 + C8/144B"
1 mg/ml in sterile PBS, BSA free, sodium azide free. CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8a/b) or as a homodimer (CD8a/a). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. Protein function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. [The UniProt Consortium]
Keywords: | Anti-MAL, Anti-CD8a, Anti-CD8A, Anti-T-cell surface glycoprotein CD8 alpha chain, Anti-T-lymphocyte differentiation antigen T8/Leu-2, CD8a Antibody Cocktail |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V3134SAF |
Properties
Application: | FC, IF, IHC |
Antibody Type: | Mixed |
Clone: | C8/468 + C8/144B |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Human recombinant protein (C8/468) and 13 amino acid peptide from the C-terminal cytoplasmic domain of the alpha chain of human CD8 (C8/144B) were used as the immunogens for this CD8a antibody cocktail. |
Format: | Purified |
Database Information
KEGG ID : | K06458 | Matching products |
UniProt ID : | P01732 | Matching products |
Gene ID | GeneID 925 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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