Anti-CD63 (Late Endosomes Marker)(NKI/C3 + LAMP3/968)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-36-1964-100 100 µg -

3 - 11 business days*

853.00€
 
This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. The tetraspanins are... more
Product information "Anti-CD63 (Late Endosomes Marker)(NKI/C3 + LAMP3/968)"
This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression. Protein function: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. [The UniProt Consortium]
Keywords: Anti-CD63, Anti-MLA1, Anti-OMA81H, Anti-LAMP-3, Anti-Tspan-30, Anti-CD63 antigen, Anti-Granulophysin, Anti-Tetraspanin-30, Anti-Melanoma-associated antigen ME491, Anti-Ocular melanoma-associated antigen, Anti-Lysosomal-associated membrane protein 3, Monoc
Supplier: Abeomics
Supplier-Nr: 36-1964

Properties

Application: FC, IF, IHC
Antibody Type: Monoclonal
Clone: NKI/C3 + LAMP3/968
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Smooth plasma membrane fraction of MeWo cells (NKI/C3), Recombinant human full-length CD63 protein (LAMP3/968)
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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