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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-36-2518-20 | 20 µg | - |
3 - 11 business days* |
375.00€
|
|||
ABE-36-2518-100 | 100 µg | - |
3 - 11 business days* |
853.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recognizes an N-glycosylated glycoprotein of 120kDa with intra-chain disulfide bonds, identified... more
Product information "Anti-CD50 / ICAM3 Monoclonal Antibody (Clone: 101-1D2)"
Recognizes an N-glycosylated glycoprotein of 120kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3 (WS: IV V). Its epitope localizes in the D2 extracellular domain and is resistant to neuraminidase and proteases. CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signalling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C. This MAb inhibits primary mixed lymphocyte culture (MLC) but not secondary MLC, cytotoxicity or proliferation induced by mitogens. It blocks binding of NK1-L16 stimulated T cells to L cells expressing CD50. This MAb is excellent for staining of formalin/paraffin tissues. Protein function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha- L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). [The UniProt Consortium]
Keywords: | Anti-CD50, Anti-CDw50, Anti-ICAM3, Anti-ICAM-3, Anti-ICAM-R, Anti-Intercellular adhesion molecule 3, Anti-CD50 / ICAM3 Monoclonal Antibody (Clone: 101-1D2) |
Supplier: | Abeomics |
Supplier-Nr: | 36-2518 |
Properties
Application: | FC, IF, IHC |
Antibody Type: | Monoclonal |
Clone: | 101-1D2 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Stimulated human leukocytes |
Database Information
KEGG ID : | K06486 | Matching products |
UniProt ID : | P32942 | Matching products |
Gene ID : | GeneID 3385 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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