Anti-CD46, clone 169-1-E4.3

Anti-CD46, clone 169-1-E4.3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2700-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V2700-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of... more
Product information "Anti-CD46, clone 169-1-E4.3"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 52kDa-58kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. Protein function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. [The UniProt Consortium]
Keywords: Anti-MCP, Anti-TLX, Anti-CD46, Anti-Membrane cofactor protein, Anti-Trophoblast leukocyte common antigen, CD46 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2700

Properties

Application: FC, IF
Antibody Type: Monoclonal
Clone: 169-1-E4.3
Conjugate: No
Host: Mouse
Species reactivity: human, baboon
Immunogen: Stimulated human leukocytes
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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