Anti-CD46, clone 122.2

Anti-CD46, clone 122.2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2190SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. CD46 acts as a cofactor for complement... more
Product information "Anti-CD46, clone 122.2"
1 mg/ml in sterile PBS, BSA free, sodium azide free. CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. Protein function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. [The UniProt Consortium]
Keywords: Anti-MCP, Anti-TLX, Anti-CD46, Anti-Membrane cofactor protein, Anti-Trophoblast leukocyte common antigen, CD46 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2190SAF

Properties

Application: WB, FC, IHC, ELISA, IP, IF
Antibody Type: Monoclonal
Clone: 122.2
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant human CD46 protein was used as the immunogen for this antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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