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![Anti-CD3E, CT (T-cell Surface Glycoprotein CD3 epsilon Chain, T-cell Surface Antigen T3/Leu-4 epsilo](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C2254-18E.50 | 50 µg | - | - |
3 - 19 business days* |
789.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Monoclonal antibodies clustered as CD3 recognize the constant structure of the CD3/TcR (T cell... more
Product information "Anti-CD3E, CT (T-cell Surface Glycoprotein CD3 epsilon Chain, T-cell Surface Antigen T3/Leu-4 epsilo"
Monoclonal antibodies clustered as CD3 recognize the constant structure of the CD3/TcR (T cell receptor) complex. This complex is present on mature T cells and during thymopoiesis. CD3/TcR is called the T cell receptor complex. This complex is composed of different structures, i.e. TcRa, TcRb, TcRg, TcRd, CD3g, CD3d, CD3e, the x-chain, and the h-chain. Less than 10% of human peripheral T cells express the g/d TcR complex. The function of a/b and g/d heterodimers is the recognition of peptide antigen bound to MHC, followed by T cell activation. Recent data suggest that CD3 chains are able to function autonomously in signal transduction. T cells play a major role in activation processes of the immune system. Detection of these cells is important during immune monitoring. In addition, a large number of leukemias are T cell-related disorders, in which antibodies recognizing CD3/TcR complex are important diagnostic tools. Differentiation between AML, T-ALL and B-ALL can be made by immunophenotyping with (early) differentiation markers. Cell surface detection using CD3 antibodies can be applied for detection of mature T-ALL, while immature T-ALL express cytoplasmic (cyCD3) but no surface CD3. CD3 antibodies are used, in characterization of various subtypes of chronic lymphoid leukemias. Examples of these chronic T cell leukemias are T-CLL (Sezary Syndrome) and the peripheral T cell lymphoma (ATLL) which co-express CD2, CD3, CD4 and CD5 antigens. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml, Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-T3E, Anti-CD3e, Anti-CD3E, Anti-T-cell surface glycoprotein CD3 epsilon chain, Anti-T-cell surface antigen T3/Leu-4 epsilon chain |
Supplier: | United States Biological |
Supplier-Nr: | C2254-18E |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide corresponding to human CD3 at C-terminal (KLH). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06451 | Matching products |
UniProt ID : | P07766 | Matching products |
Gene ID | GeneID 916 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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