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![Anti-CD32, clone 8.7](https://www.biomol.com/media/image/ca/c8/d6/NSJ-V2496SAF-100UG_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V2496SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in sterile PBS, BSA free, sodium azide free. This mAb reacts with a CD32 (FcgRII) epitope... more
Product information "Anti-CD32, clone 8.7"
1 mg/ml in sterile PBS, BSA free, sodium azide free. This mAb reacts with a CD32 (FcgRII) epitope distinct from that defined by mAb 8.26 and the epitope overlaps with that of mAb 7.30 (cluster 4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcgRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes. Protein function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. [The UniProt Consortium]
Keywords: | Anti-CD32, Anti-CDw32, Anti-FCGR2A, Anti-FcRII-a, Anti-Fc-gamma-RIIa, Anti-Fc-gamma RII-a, Anti-IgG Fc receptor II-a, Anti-Low affinity immunoglobulin gamma Fc region receptor II-a, CD32 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V2496SAF |
Properties
Application: | FA (activity), FC, IF |
Antibody Type: | Monoclonal |
Clone: | 8.7 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | K562 and FcgRII+L cells |
Format: | Purified |
Database Information
KEGG ID : | K06472 | Matching products |
UniProt ID : | P12318 | Matching products |
Gene ID | GeneID 2212 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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