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![Anti-CD31, clone MEM-05 (PE)](https://www.biomol.com/media/image/8d/88/be/ARG53828-100_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG53828.100 | 100 tests | - | - |
6 - 14 business days* |
662.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Induces susceptibility to atherosclerosis. Cell adhesion molecule which is... more
Product information "Anti-CD31, clone MEM-05 (PE)"
Protein function: Induces susceptibility to atherosclerosis. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC). [The UniProt Consortium]
Keywords: | Anti-CD31, Anti-PECA1, Anti-PECAM1, Anti-GPIIA', Anti-PECAM-1, Anti-EndoCAM, Anti-Platelet endothelial cell adhesion molecule |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG53828 |
Properties
Application: | FC, WB |
Antibody Type: | Monoclonal |
Clone: | MEM-05 |
Conjugate: | Phycoerythrin |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Leukocytes of patient suffering from LGL-type leukaemia |
Format: | Liquid |
Database Information
KEGG ID : | K06471 | Matching products |
UniProt ID : | P16284 | Matching products |
Gene ID | GeneID 5175 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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