Anti-CD3 epsilon, clone 145-2C11

Anti-CD3 epsilon, clone 145-2C11
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V8271-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V8271-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. CD3 chains. CD3 plays a critical... more
Product information "Anti-CD3 epsilon, clone 145-2C11"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. CD3 chains. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex. The 145-2C11 antibody is useful for in vitro blocking and activation assays, as well as apoptosis induction and in vivo T cell depletion. Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down- regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128). [The UniProt Consortium]
Keywords: Anti-T3E, Anti-CD3e, Anti-CD3E, Anti-T-cell surface glycoprotein CD3 epsilon chain, Anti-T-cell surface antigen T3/Leu-4 epsilon chain, CD3 epsilon Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V8271

Properties

Application: FA, FC, IF
Antibody Type: Monoclonal
Clone: 145-2C11
Conjugate: No
Species reactivity: mouse
Immunogen: The H2Kb-specific mouse cytotoxic T lymphocyte clone BM10 37
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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