Anti-CD3 delta / CD3D, clone IDE-3

Anti-CD3 delta / CD3D, clone IDE-3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ5046 100 µl - -

3 - 10 business days*

755.00€
 
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. 'T-cell surface... more
Product information "Anti-CD3 delta / CD3D, clone IDE-3"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. 'T-cell surface glycoprotein CD3 delta chain' is part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456). [The UniProt Consortium]
Keywords: Anti-T3D, Anti-CD3d, Anti-CD3D, Anti-T-cell receptor T3 delta chain, Anti-T-cell surface glycoprotein CD3 delta chain, CD3 delta Antibody / CD3D
Supplier: NSJ Bioreagents
Supplier-Nr: RQ5046

Properties

Application: WB
Antibody Type: Monoclonal
Clone: IDE-3
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A synthetic peptide specific to human CD3D
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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