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![Anti-CD274 (CD274 Antigen, B7 Homolog 1, B7H1, B7-H1, B7-H, MGC142294, MGC142296, OTTHUMP00000021029](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C2549-22E1.100 | 100 µg | - | - |
3 - 19 business days* |
568.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD274, also known as B7-H1 and PD-1L, is a cell surface glycoprotein which is a member of the B7... more
Product information "Anti-CD274 (CD274 Antigen, B7 Homolog 1, B7H1, B7-H1, B7-H, MGC142294, MGC142296, OTTHUMP00000021029"
CD274, also known as B7-H1 and PD-1L, is a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to Interferons alpha, beta and gamma. CD274 is reported to possess dual functions, inhibition of activated effector T cells and co-stimulation of naïve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1, PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early T cell priming and differentiation., Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: Neat-1:10, 10ul labels 1x10e6 cells in 100ul., Optimal dilutions to be determined by the researcher. Recommended Negative Control: I1904-78R: IgG1 Murine Negative Control, Hybridoma: Cells from immunized mice were fused with cells of the P3U1 myeloma cell line. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-B7H1, Anti-CD274, Anti-B7-H1, Anti-PD-L1, Anti-B7 homolog 1, Anti-PDCD1 ligand 1, Anti-Programmed death ligand 1, Anti-Programmed cell death 1 ligand 1 |
Supplier: | United States Biological |
Supplier-Nr: | C2549-22E1 |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | 10B1199 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Human CD274 transfected P815 cells. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06745 | Matching products |
UniProt ID : | Q9NZQ7 | Matching products |
Gene ID | GeneID 29126 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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