Anti-CD27/TNFRSF7 (Capture/Detector)

Anti-CD27/TNFRSF7 (Capture/Detector)
NEW
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AN004010P.25 25 µg - -

7 - 16 business days*

158.00€
E-AN004010P.100 100 µg - -

7 - 16 business days*

426.00€
E-AN004010P.1 1 mg - -

7 - 16 business days*

1,715.00€
 
CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the... more
Product information "Anti-CD27/TNFRSF7 (Capture/Detector)"
CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis. Protein function: Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:11062504). Mechanistically, CD70 ligation activates the TRAF2- PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (PubMed:15723067). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (PubMed:38386557). [The UniProt Consortium]
Keywords: Anti-CD27, Anti-CD27 antigen, Anti-CD27L receptor, Anti-T-cell activation antigen CD27, Anti-Tumor necrosis factor receptor superfamily member 7, CD27/TNFRSF7 Polyclonal Antibody(Capture/Detector)
Supplier: Elabscience
Supplier-Nr: E-AN004010P

Properties

Application: ELISA Capture/Detector
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human,mouse,rat
Immunogen: Recombinant Mouse CD27/TNFRSF7 Protein expressed by Mammalian

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-CD27/TNFRSF7 (Capture/Detector)"
Write a review
or to review a product.
Viewed