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![Anti-CD261 / TRAIL-R1 / DR4 Monoclonal Antibody (Clone:DR-4-02)](https://www.biomol.com/media/image/df/b2/ea/ABE-30-1276-0-1_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1276-0.1 | 100 µg | - |
3 - 11 business days* |
653.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand... more
Product information "Anti-CD261 / TRAIL-R1 / DR4 Monoclonal Antibody (Clone:DR-4-02)"
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor). Protein function: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. [The UniProt Consortium]
Keywords: | Anti-APO2, Anti-CD261, Anti-TRAIL-R1, Anti-TNFRSF10A, Anti-TRAIL receptor 1, Anti-Death receptor 4, Anti-TNF-related apoptosis-inducing ligand receptor 1, Anti-Tumor necrosis factor receptor superfamily member 10A, Anti-CD261 / TRAIL-R1 / DR4 Monoclonal A |
Supplier: | Abeomics |
Supplier-Nr: | 30-1276 |
Properties
Application: | FC, IP, ICC, FA |
Antibody Type: | Monoclonal |
Clone: | DR-4-02 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04722 | Matching products |
UniProt ID : | O00220 | Matching products |
Gene ID | GeneID 8797 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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You will get a certificate here
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