Anti-CD261 (human), Azide Free Clone B-N36 [Mouse]

Specificity: Recognises a 43-46 kDa protein, Format: Phosphate-buffered saline. Sterile-filtered through 0.22 µm and treated to remove endotoxins. Carrier and preservative free, Storage: Store at +2-8°C for 12 months. For longer storage, freeze aliquots, Application Notes: Neutralizes TRAIL induced apoptosis on HEL cell line Protein function: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF- kappa-B (PubMed:9430227). [The UniProt Consortium]