Anti-CD200 (Capture/Detector)

CD200 (OX2) and CD200R (OX2R) are membrane glycoprotein members of the Ig superfamily. CD200 is expressed by a range of cells, including neurons, epithelial cells, endothelial cells, fibroblasts, and lymphoid cells, while its receptor, CD200R, is found on myeloid and T cells. Interaction between CD200 and CD200R downregulates macrophage function and plays a role in immunosuppression and regulation of anti-tumor immune responses. Protein function: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. [The UniProt Consortium]