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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R30670 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CD168, or HMMR (Hyaluronan-mediated... more
Product information "Anti-CD168"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CD168, or HMMR (Hyaluronan-mediated motility receptor), is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, CD168 does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. It normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of CD168 to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, it associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, it associates with CD44, and upon binding to HA, activates intracellular signaling pathways. Protein function: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. [The UniProt Consortium]
Keywords: | Anti-HMMR, Anti-CD168, Anti-IHABP, Anti-Hyaluronan mediated motility receptor, Anti-Receptor for hyaluronan-mediated motility, Anti-Intracellular hyaluronic acid-binding protein, CD168 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R30670 |
Properties
Application: | WB, IHC (paraffin) |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | An amino acid sequence from the C-terminus of human CD168 (KEGNTNCYRAPMECQESWK) was used as the immunogen for this CD168 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K06267 | Matching products |
UniProt ID : | O75330 | Matching products |
Gene ID : | GeneID 3161 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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