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![Anti-CD16, clone ICO-116](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V2501SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in sterile PBS, BSA free, sodium azide free. It recognizes CD16 (Fcgamma,RIII), the... more
Product information "Anti-CD16, clone ICO-116"
1 mg/ml in sterile PBS, BSA free, sodium azide free. It recognizes CD16 (Fcgamma,RIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16, CD16A (Fcgamma,RIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fcgamma,RIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation. Protein function: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. [The UniProt Consortium]
Keywords: | Anti-CD16A, Anti-CD16a, Anti-FCGR3A, Anti-FcR-10, Anti-FcRIII, Anti-FcRIIIa, Anti-Fc-gamma RIII, Anti-CD16a antigen, Anti-Fc-gamma RIIIa, Anti-Fc-gamma RIII-alpha, Anti-IgG Fc receptor III-2, Anti-Low affinity immunoglobulin gamma Fc region receptor III-A |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V2501SAF |
Properties
Application: | FC, IF |
Antibody Type: | Monoclonal |
Clone: | ICO-116 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Human CD16 protein |
Format: | Purified |
Database Information
KEGG ID : | K06463 | Matching products |
UniProt ID : | P08637 | Matching products |
Gene ID | GeneID 2214 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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