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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-12-9441-10 | 10 µg | - |
3 - 11 business days* |
585.00€
|
|||
ABE-12-9441-100 | 100 µg | - |
3 - 11 business days* |
1,050.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description :Anti-CCR1 antibody(DMC465), IgG1 Chimeric mAbThis gene encodes a member of the beta... more
Product information "Anti-CCR1 antibody(DMC465), IgG1 Chimeric mAb"
Description :Anti-CCR1 antibody(DMC465), IgG1 Chimeric mAbThis gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008] Protein function: Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:14991608). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (PubMed:15905581). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4. Mediates also monocyte migration upon CXCL4 binding (PubMed:29930254). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway. [The UniProt Consortium]
Keywords: | Anti-CCR1, Anti-CCR-1, Anti-CD191, Anti-HM145, Anti-CMKBR1, Anti-CC-CKR-1, Anti-RANTES-R, Anti-C-C CKR-1, Anti-MIP-1alpha-R, Anti-LD78 receptor, Anti-C-C chemokine receptor type 1, Anti-Macrophage inflammatory protein 1-alpha receptor, Anti-CCR1 antibody( |
Supplier: | Abeomics |
Supplier-Nr: | 12-9441 |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | DMC465 |
Conjugate: | No |
Host: | Rabbit/Human |
Species reactivity: | human |
Format: | Lyophilized |
Database Information
KEGG ID : | K04176 | Matching products |
UniProt ID : | P32246 | Matching products |
Gene ID : | GeneID 1230 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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