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![Anti-CCND1](https://www.biomol.com/media/image/ce/26/73/NSJ-F52187-0-08ML_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F52187-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F52187-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. Cyclins function as regulators of CDK kinases.... more
Product information "Anti-CCND1"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Protein function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. [The UniProt Consortium]
Keywords: | Anti-BCL1, Anti-CCND1, Anti-BCL-1, Anti-PRAD1 oncogene, Anti-BCL-1 oncogene, Anti-G1/S-specific cyclin-D1, Anti-B-cell lymphoma 1 protein, CCND1 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F52187 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | A portion of amino acids 264-292 from the human protein was used as the immunogen for this CCND1 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K04503 | Matching products |
UniProt ID : | P24385 | Matching products |
Gene ID | GeneID 595 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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