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Product information "Anti-CCL2/JE/MCP-1 (Capture/Detector)"
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases. Migration of monocytes from the blood stream across the vascular endothelium is required for routine immunological surveillance of tissues,as well as in response to inflammation. Protein function: Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:10529171, PubMed:10587439, PubMed:9837883). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8195247, PubMed:8627182, PubMed:9792674). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690). [The UniProt Consortium]
Keywords:
Anti-HC11, Anti-MCAF, Anti-CCL2, Anti-MCP1, Anti-MCP-1, Anti-C-C motif chemokine 2, Anti-Small-inducible cytokine A2, Anti-Monocyte secretory protein JE, Anti-Monocyte chemotactic protein 1, Anti-Monocyte chemoattractant protein 1, CCL2/JE/MCP-1 Polyclona
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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