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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-20T-0137-C100 | 100 µg | - |
3 - 9 business days* |
319.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a... more
Product information "Anti-Caspase-8 (mouse), clone 1G12"
Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p20, respectively, which leads to the generation of the active caspase-8 heterotetramer (p20/p10)2.
Keywords: | Anti-Casp8, EC=3.4.22.61 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-20T-0137 |
Properties
Application: | ELISA, FC, ICC, WB |
Antibody Type: | Monoclonal |
Clone: | 1G12 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | mouse |
Immunogen: | Recombinant mouse caspase-8 (p20 subunit) |
Purity: | >95% |
Format: | Purified |
Database Information
KEGG ID : | K04398 | Matching products |
UniProt ID : | O89110 | Matching products |
Gene ID | GeneID 12370 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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