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![Anti-Caspase-4/11 (p20), clone Flamy-1, Biotin conjugated](https://www.biomol.com/media/image/65/85/9e/AG-20B-0060B-C100_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-20B-0060B-C100 | 100 µg | - |
3 - 9 business days* |
413.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recognizes endogenous full-length protein and activated (p20) fragment of mouse and human... more
Product information "Anti-Caspase-4/11 (p20), clone Flamy-1, Biotin conjugated"
Recognizes endogenous full-length protein and activated (p20) fragment of mouse and human caspase-4/11. Liquid. Purified from concentrated hybridoma tissue culture supernatant. Inflammatory caspases (also known as group I caspases) are encoded by three main genes in humans, caspase-1, caspase-4 and caspase-5 and three main genes in mouse, caspase-1, caspase-11 and caspase-12. Caspase-11 is the murine orthologue of human caspase-4 and -5. Murine caspase-11 is a poorly characterized member of the caspase-1 subfamily. Caspase-11-deficient embryonic fibroblasts are resistant to apoptosis induced by ectopic expression of caspase-1, suggesting that caspase-11 is an upstream activator of caspase-1. Unlike caspase-1, the expression of caspase-11 is LPS-inducible and it is reasonable to postulate that other members of the family are regulated at the transcriptional or translational level by extracellular stimuli.Recently caspase-11 has been shown to be required for activation of the Nlrp3 inflammasome upon E. coli, V. cholerae and C. rodentium infection. The upstream activators of Caspase-11 are TLR4 and TRIF, that modulate enteropathogen-induced inflammasome activation by promoting caspase-11 expression and activation. Formation of ASC foci (specks), a measure of NLRP3/ASC complex formation, requires caspase-11 but not caspase-1 indicating that caspase-11 acts upstream of the NLRP3/ASC complex.
Keywords: | Anti-Caspase-11 (mouse),Anti- Caspase-4 (human), Anti-ICE(rel)-II (human), Protease ICH-2 (human), Protease TX (human), Protease ICH-3 (mouse) |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-20B-0060B |
Properties
Application: | IP, WB |
Antibody Type: | Monoclonal |
Clone: | Flamy-1 |
Conjugate: | Biotin |
Host: | mouse |
Species reactivity: | human, mouse |
Immunogen: | Recombinant mouse Caspase-11 (aa 81-373). |
Purity: | >95% |
Format: | Purified |
Database Information
KEGG ID : | K04394 | Matching products |
UniProt ID : | P70343 | Matching products |
Gene ID | GeneID 12363 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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