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![Anti-Caspase 11](https://www.biomol.com/media/image/23/5e/10/ARG43386-100_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG43386.100 | 100 µl | - | - |
6 - 14 business days* |
624.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Inflammatory caspase that acts as an essential effector of NLRP3... more
Product information "Anti-Caspase 11"
Protein function: Inflammatory caspase that acts as an essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria (PubMed:8702803, PubMed:9038361, PubMed:22002608, PubMed:25119034). Thiol protease that cleaves a tetrapeptide after an Asp residue at position P1. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, followed by IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:22002608, PubMed:26320999, PubMed:26375003). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection: in later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which catalyzes cleavage of GSDMD, resulting in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion (PubMed:25121752, PubMed:26375003). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32554464, PubMed:32109412). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752). Involved in LPS-induced IL6 secretion, this activity may not require caspase enzymatic activity. Involved in cell death induced by endoplasmic reticulum stress. Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:8702803, PubMed:9038361). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). {ECO:0000250, UniProtKB:P49662, ECO:0000269, PubMed:22002608, ECO:0000269, PubMed:25119034, ECO:0000269, PubMed:25121752, ECO:0000269, PubMed:26320999, ECO:0000269, PubMed:26375003, ECO:0000269, PubMed:28314590, ECO:0000269, PubMed:32109412, ECO:0000269, PubMed:32554464, ECO:0000269, PubMed:8702803, ECO:0000269, PubMed:9038361}. [The UniProt Consortium]
Keywords: | Anti-CASP-4, Anti-Caspase-4, Anti-CASP-11 {ECO:0000303|Ref.3}, Anti-Caspase-11 {ECO:0000303|Ref.3}, Anti-Protease ICH-3 {ECO:0000303|PubMed:8702803}, Anti-Caspase-4 subunit p10 {ECO:0000305|PubMed:32109412}, Anti-Caspase-4 subunit p20 {ECO:0000305|PubMed: |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG43386 |
Properties
Application: | IP, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse, rat |
Immunogen: | Recombinant protein of Mouse Caspase 11 |
MW: | 43 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04394 | Matching products |
UniProt ID : | P70343 | Matching products |
Gene ID | GeneID 12363 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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