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![Anti-Carbamylated Alpha-1 Antitrypsin (K359)](https://www.biomol.com/media/image/9c/10/cd/Cay25340-500_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay25340-500 | 500 µl | - |
6 - 10 business days* |
535.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Alpha-1 antitrypsin is a serine protease inhibitor and member of the serpin superfamily. It has a... more
Product information "Anti-Carbamylated Alpha-1 Antitrypsin (K359)"
Alpha-1 antitrypsin is a serine protease inhibitor and member of the serpin superfamily. It has a five-stranded A beta-sheet and a mobile reactive center loop that acts as a pseudosubstrate for various proteases. Alpha-1 antitrypsin binds to a protease, undergoes proteolytic cleavage, and forms a covalent linkage between a carboxyl group in the reactive loop and the serine hydroxyl of the protease active site, effectively inactivating the enzyme which is then cleared from circulation. The primary targets of alpha-1 antitrypsin are neutrophil elastase and proteinase 3, however, it also inhibits trypsin, kallikreins 7 and 14, and matriptase. Alpha-1 antitrypsin protects the lower respiratory tract from proteolytic destruction via inhibition of neutrophil elastase and reduced serum levels of alpha-1 antitrypsin have been linked to early-onset liver disease and emphysema. Alpha-1 antitrypsin is an acute-phase protein that reduces production of inflammatory cytokines, inhibits apoptosis, blocks leukocyte degranulation and migration, as well as suppresses NF-kappaB nuclear translocation in monocytes. It delays disease onset in mouse models of inflammatory disease, including collagen-induced arthritis and experimental autoimmune encephalomyelitis (EAE). Alpha-1 antitrypsin is subject to post-translational modifications such as glycosylation and carbamylation in vivo. Carbamylated alpha-1 antitrypsin has been found in synovial fluid samples from rheumatoid arthritis patients and is predicted to act as an autoantigen. Cayman's Carbamylated Alpha-1 Antitrypsin (K359) Polyclonal Antibody can be used for Western blot applications. This antibody recognizes carbamylated alpha-1 antitrypsin at ~47 kDa from human samples.Synonyms: Carbamylated A1AT, Carbamylated AAT, Alpha-1 Antitrypsin (Homocitrulline 359), Carbamylated alpha1-Antitrypsin. Immunogen: Synthetic peptide surrounding homocitrulline 359 (335 of the mature enzyme) of human alpha-1 antitrypsin. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: WB. Cross Reactivity: (+) Carbamylated A1AT, (-) Non-carbamylated proteins. UniProt Accession #: P01009.
Keywords: | Anti-AAT, Anti-SPAAT, Anti-PRO0684, Anti-Serpin A1, Anti-Alpha-1-antitrypsin, Anti-Alpha-1-antiproteinase, Anti-Short peptide from AAT, Anti-Alpha-1 protease inhibitor |
Supplier: | Cayman Chemical |
Supplier-Nr: | 25340 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide surrounding homocitrulline 359 (335 of the mature enzyme) of human alpha-1 antitrypsin |
Format: | Solid |
Database Information
KEGG ID : | K03984 | Matching products |
UniProt ID : | P01009 | Matching products |
Gene ID | GeneID 5265 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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