Anti-BubR1 (IHC)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IHC-00498-T	10 µl (2500 ng)		-		2 - 8 business days*		164.00€
IHC-00498	100 µl (25 µg)		-		2 - 8 business days*		623.00€

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Protein function: Essential component of the mitotic checkpoint. Required for normal mitosis... more

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Product information "Anti-BubR1 (IHC)"

Protein function: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [The UniProt Consortium]

Keywords:	Anti-BUB1B, Anti-BUBR1, Anti-hBUBR1, EC=2.7.11.1, Anti-Protein SSK1, Anti-Mitotic checkpoint kinase MAD3L, Anti-MAD3/BUB1-related protein kinase, Anti-Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Supplier:	Bethyl Laboratories
Supplier-Nr:	IHC-00498

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: orangutan, rhesus monkey, gorilla, chimpanzee, crab-eating macaque)
Immunogen:	synthetic peptide. The epitope recognized by IHC-00498 maps to a region between residue 1 and 50 of human budding uninhibited by benzimidazoles 1 homolog beta using the numbering given in entry NP_001202.3 (GeneID 701).
Format:	Antigen Affinity Purified