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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
MON-MON9050 | 1 ml | - | - |
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377.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Broad substrate specificity ATP-dependent transporter of the ATP-binding... more
Product information "Anti-Breast Cancer Resistance Protein (ABCG2), clone BXP-9 (Monoclonal) [Rat]"
Protein function: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:10485464, PubMed:12477054, PubMed:12429862, PubMed:17145775, PubMed:30042379). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:12429862, PubMed:15044468). Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (PubMed:30042379). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy- androst-5-en-17-one/DHEAS, and other sulfate conjugates. Mediates the secretion of the riboflavin and biotin vitamins into milk (PubMed:17145775). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (PubMed:12429862). Plays an important role in the exclusion of xenobiotics from the brain (PubMed:10485464). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:12477054). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (PubMed:12429862). May play a role in early stem cell self-renewal by blocking differentiation (Probable). [The UniProt Consortium]
Keywords: | Anti-Abcp, Anti-Abcg2, Anti-CD338, Anti-Urate exporter, Anti-Breast cancer resistance protein 1 homolog, Anti-ATP-binding cassette sub-family G member 2, Anti-Broad substrate specificity ATP-binding cassette transporter ABCG2, Rat anti-Breast Cancer Resis |
Supplier: | MONOSAN |
Supplier-Nr: | MON9050 |
Properties
Application: | FC, ICC, IHC, WB |
Antibody Type: | Monoclonal |
Clone: | BXP-9 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | human |
Immunogen: | BCRP aa 221-394 |
Database Information
KEGG ID : | K05681 | Matching products |
UniProt ID : | Q7TMS5 | Matching products |
Gene ID : | GeneID 26357 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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