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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A700-319-T | 20 µl (2 blots) | - |
2 - 8 business days* |
172.00€
|
|||
A700-319 | 100 µl (10 blots) | - |
2 - 8 business days* |
655.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and... more
Product information "Anti-BRCA1 Recombinant Monoclonal"
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. Protein function: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. [The UniProt Consortium]
Keywords: | Anti-Breast cancer type 1 susceptibility protein homolog |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A700-319 |
Properties
Application: | WB, IP, FC |
Antibody Type: | Monoclonal |
Clone: | BLR319M |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K10605 | Matching products |
UniProt ID : | Q6NV63 | Matching products |
Gene ID | GeneID 12189 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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