Anti-BIG1/ARFGEF1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-998A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A300-998A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation... more

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Product information "Anti-BIG1/ARFGEF1"

Protein function: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure, the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. [The UniProt Consortium]

Keywords:	Anti-ARFGEF1, Anti-ARFGEP1, Anti-p200 ARF-GEP1, Anti-Brefeldin A-inhibited GEP 1, Anti-p200 ARF guanine nucleotide exchange factor, Anti-Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-998A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat, bovine)
Immunogen:	synthetic peptide. The epitope recognized by A300-998A-T maps to a region between residue 1800 and the C-terminus (residue 1849) of human brefeldin A-inhibited guanine nucleotide-exchange protein 1 using the numbering given in entry NP_006412.2 (GeneID 10565).
Format:	Antigen Affinity Purified