Anti-Beta-2 Microglobulin (Renal Failure & Tumor Marker) Recombinant Rabbit Monoclonal Antibody (clo

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-12-1082-20 20 µg -

3 - 11 business days*

373.00€
 
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility... more
Product information "Anti-Beta-2 Microglobulin (Renal Failure & Tumor Marker) Recombinant Rabbit Monoclonal Antibody (clo"
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes. Protein function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). [The UniProt Consortium]
Keywords: Anti-CDABP0092, Anti-Beta-2 Microglobulin (Renal Failure & Tumor Marker) Recombinant Rabbit Monoclonal Antibody (Clone:B2M/1857R)
Supplier: Abeomics
Supplier-Nr: 12-1082-20

Properties

Application: IHC
Antibody Type: Monoclonal
Clone: B2M/1857R
Conjugate: No
Host: Rabbit
Species reactivity: human, non-human primates
Immunogen: Recombinant full-length human B2M protein
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Beta-2 Microglobulin (Renal Failure & Tumor Marker) Recombinant Rabbit Monoclonal Antibody (clo"
Write a review
or to review a product.
-30 %
Discount Promotion
-30 %
Discount Promotion
-30 %
Discount Promotion
-30 %
Discount Promotion
-30 %
Discount Promotion
-30 %
Discount Promotion
-30 %
Discount Promotion
Anti-beta 2 Microglobulin, clone B2M-01 Anti-beta 2 Microglobulin, clone B2M-01
436.00€ * From 305.20€ *
-30 %
Discount Promotion
-30 %
Discount Promotion
Viewed