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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-12-1082-20 | 20 µg | - |
3 - 11 business days* |
373.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility... more
Product information "Anti-Beta-2 Microglobulin (Renal Failure & Tumor Marker) Recombinant Rabbit Monoclonal Antibody (clo"
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes. Protein function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). [The UniProt Consortium]
Keywords: | Anti-CDABP0092, Anti-Beta-2 Microglobulin (Renal Failure & Tumor Marker) Recombinant Rabbit Monoclonal Antibody (Clone:B2M/1857R) |
Supplier: | Abeomics |
Supplier-Nr: | 12-1082-20 |
Properties
Application: | IHC |
Antibody Type: | Monoclonal |
Clone: | B2M/1857R |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, non-human primates |
Immunogen: | Recombinant full-length human B2M protein |
Format: | Purified |
Database Information
KEGG ID : | K08055 | Matching products |
UniProt ID : | P61769 | Matching products |
Gene ID : | GeneID 567 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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