Anti-Beta-2 Microglobulin, clone B2M/1857R

Anti-Beta-2 Microglobulin, clone B2M/1857R
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3539SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes a protein of 12kDa, identified as... more
Product information "Anti-Beta-2 Microglobulin, clone B2M/1857R"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes. Protein function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). [The UniProt Consortium]
Keywords: Anti-B2M, Anti-CDABP0092, Beta-2 Microglobulin Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3539SAF

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: B2M/1857R
Conjugate: No
Host: Rabbit
Species reactivity: human, primates
Immunogen: Full length recombinant human protein was used as the immunogen for the recombinant B2M antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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