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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-12-1075-100 | 100 µg | - |
3 - 11 business days* |
850.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This antibody recognizes a protein of 25-26kDa, identified as the bcl-2lpha oncoprotein. It shows... more
Product information "Anti-Bcl-2 (Apoptosis& Follicular Lymphoma Marker) Recombinant Rabbit Monoclonal Antibody (clone:BCL"
This antibody recognizes a protein of 25-26kDa, identified as the bcl-2lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression ofbcl-2lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative. Protein function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). [The UniProt Consortium]
Keywords: | Anti-BCL2, Anti-Apoptosis regulator Bcl-2, Anti-Bcl-2 (Apoptosis& Follicular Lymphoma Marker) Recombinant Rabbit Monoclonal Antibody (Clone:BCL2/2210R) |
Supplier: | Abeomics |
Supplier-Nr: | 12-1075 |
Properties
Application: | IHC |
Antibody Type: | Monoclonal |
Clone: | BCL2/2210R |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant full-length human bcl-2 protein |
Format: | Purified |
Database Information
KEGG ID : | K02161 | Matching products |
UniProt ID : | P10415 | Matching products |
Gene ID : | GeneID 596 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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