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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES10039.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES10039.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The... more
Product information "Anti-ATP4B"
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008], Protein function: The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Apical cell membrane , Single-pass type II membrane protein . Cell membrane , Single-pass type II membrane protein . Localized in the apical canalicular membrane of parietal cells. .
Keywords: | Anti-Proton pump beta chain, Anti-Gastric H(+)/K(+) ATPase subunit beta, Anti-Potassium-transporting ATPase subunit beta, ATP4B rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES10039 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse |
Immunogen: | Synthesized peptide derived from human protein . at AA range: 160-240 |
MW: | 32 kD |
Format: | Purified |
Database Information
KEGG ID : | K01543 | Matching products |
UniProt ID : | P51164 | Matching products |
Gene ID | GeneID 496 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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