Anti-APOBEC3G

Anti-APOBEC3G
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F40028-0.08ML 80 µl - -

3 - 10 business days*

350.00€
NSJ-F40028-0.4ML 400 µl - -

3 - 10 business days*

755.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene is a member of the cytidine deaminase gene... more
Product information "Anti-APOBEC3G"
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. Protein function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons. [The UniProt Consortium]
Keywords: Anti-A3G, Anti-ARCD, Anti-CEM15, Anti-ARP-9, Anti-CEM-15, Anti-MDS019, Anti-APOBEC3G, EC=3.5.4.-, Anti-APOBEC-related protein, Anti-Deoxycytidine deaminase, Anti-APOBEC-related protein 9, Anti-APOBEC-related cytidine deaminase, APOBEC3G Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F40028

Properties

Application: WB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A portion of amino acids 231-260 from the human protein was used as the immunogen for this APOBEC3G antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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