Anti-AMH / Anti-Muellerian Hormone, clone AMH/6713R

1 mg/ml in 1X PBS, BSA free, sodium azide free. The transforming growth factor superfamily proteins are involved in embryonic development and adult tissue homeostasis. The Muellerian inhibiting factor (MIF), also called Muellerian-inhibiting substance (MIS) and Anti-Muellerian hormone (AMH), glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIF and testosterone, the presence of which result in male offspring. Absence of MIF and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIF causes regression of the Muellerian duct. MIF inhibits the growth of tumors derived from tissues of Mullerian duct origin. It can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Protein function: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation (PubMed:3754790, PubMed:34155118, PubMed:8469238). Plays also a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:14742691). AMH signals by binding to a specific type- II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression (PubMed:20861221, PubMed:34155118). [The UniProt Consortium]