Anti-AMACR (N-Term) Rabbit Monoclonal Antibody (Clone RM349)

alpha-methylacyl-Coenzyme A (alpha-methylacyl-CoA) racemase (AMACR) is an enzyme involved in the metabolism of branched chain fatty acids and 2-arylpropanoic acids (2-APAs), such as ibuprofen (Cay-70280). It is expressed in most human tissues and is localized to peroxisomes and mitochondria. AMACR converts R-2-methyl fatty acids to S-2-methylacyl-CoA esters via an epimerization reaction prior to their degradation by beta-oxidation. AMACR is overexpressed in localized and metastatic prostate cancer, as well as in a variety of other cancers. AMACR has been found selectively in patient-derived prostate cancer tumor tissue compared to non-cancer prostate tissue, and has been used as a biomarker of the disease. Mutations in AMACR resulting in reduced enzyme activity lead to the accumulation of R-2-methyl fatty acids and are associated with neurological and peroxisomal disorders. Cayman's AMACR (N-Term) Rabbit Monoclonal Antibody (Clone RM349) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: 2-arylpropionyl-CoA Epimerase, 2-R-Ibuprofenyl racemase, alpha-methylacyl-CoA, P504S. Immunogen: Peptide from the N-terminal region of human AMACR. Clone Designation: RM349. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) AMACR.