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![Anti-Alpha 1 Antitrypsin / AAT / SERPINA1, clone AAT/1379](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V3222SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. Alpha-1 Antitrypsin or alpha1-antitrypsin (A1AT)... more
Product information "Anti-Alpha 1 Antitrypsin / AAT / SERPINA1, clone AAT/1379"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Alpha-1 Antitrypsin or alpha1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it inhibits a wide variety of proteases. It protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 1.5 - 3.5 gram/liter (in US the reference range is generally expressed as mg/dL or micromoles), but the concentration can rise manyfold upon acute inflammation. In its absence (such as in alpha 1-antitrypsin deficiency), neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children.Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Mutations in these areas can lead to non-functional proteins that can polymerise and accumulate in the liver (infantile hepatic cirrhosis). [Wiki] Protein function: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. [The UniProt Consortium]
Keywords: | Anti-AAT, Anti-PRO0684, Anti-SERPINA1, Alpha 1 Antitrypsin Antibody / AAT / SERPINA1 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V3222SAF |
Properties
Application: | WB, IHC (paraffin), FC, IF |
Antibody Type: | Monoclonal |
Clone: | AAT/1379 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A human partial recombinant protein was used as the immunogen for this Alpha 1 Antitrypsin antibody. |
Format: | Purified |
Database Information
KEGG ID : | K03984 | Matching products |
UniProt ID : | P01009 | Matching products |
Gene ID | GeneID 5265 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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