Anti-Adgrg1 / Gpr56 / Adhesion G-protein coupled receptor G1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Enables several functions, including collagen binding activity, extracellular matrix binding activity, and heparin binding activity. Involved in several processes, including negative regulation of neuron migration, positive regulation of Rho protein signal transduction, and seminiferous tubule development. Acts upstream of or within cerebral cortex regionalization, hematopoietic stem cell homeostasis, and positive regulation of neural precursor cell proliferation. Located in glial limiting end-foot. Is expressed in several structures, including alimentary system, ganglia, genitourinary system, respiratory system, and sensory organ. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1). Protein function: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (PubMed:21768377). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (PubMed:23478665). Plays a critical role in tumourigenesis. Plays essential role in testis development (PubMed:20981830). [The UniProt Consortium]