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![Anti-Actin, beta (ACTB, Actin Cytoplasmic 1, Beta Cytoskeletal Actin) (Biotin)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A0760-41K.100 | 100 µl | - | - |
3 - 19 business days* |
819.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Actin, a ubiquitous eukaryotic protein, is the major component of the cytoskeleton. At least six... more
Product information "Anti-Actin, beta (ACTB, Actin Cytoplasmic 1, Beta Cytoskeletal Actin) (Biotin)"
Actin, a ubiquitous eukaryotic protein, is the major component of the cytoskeleton. At least six isoforms are known in mammals. Nonmuscle b- and g-actin, also known as cytoplasmic actin, are predominantly expressed in nonmuscle cells, controlling cell structure and motility (1). a-cardiac anda-skeletal actin are expressed in striated cardiac and skeletal muscles, respectively, two smooth muscle actins, a- and g-actin, are found primarily in vascular smooth muscle and enteric smooth muscle, respectively. These actin isoforms regulate the contractile potential of muscle cells (1). Actin exists mainly as a fibrous polymer, F-actin. In response to cytoskeletal reorganizing signals during processes such as cytokinesis, endocytosis, or stress, cofilin promotes fragmentation and depolymerization of F-actin, resulting in an increase in the monomeric globular form, G-actin (2). The Arp2/3 complex stabilizes F-actin fragments and promotes formation of new actin filaments (2). It has been reported that actin is hyperphosphorylated in primary breast tumors (3). Cleavage of actin under apoptotic conditions has been observed in vitro and in cardiac and skeletal muscle (4-6). Actin cleavage by caspase-3 may accelerate ubiquitin/proteosome dependent muscle proteolysis (6). Applications: Suitable for use in Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:200, Western Blot: 1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-ACTB, Anti-Beta-actin, Anti-Actin, cytoplasmic 1, Anti-Actin, cytoplasmic 1, N-terminally processed |
Supplier: | United States Biological |
Supplier-Nr: | A0760-41K |
Properties
Application: | FC, WB |
Antibody Type: | Monoclonal |
Clone: | 10g129(13E5) |
Conjugate: | Biotin |
Host: | Rabbit |
Species reactivity: | bovine, human, monkey, mouse, swine, rat |
Immunogen: | Synthetic peptide corresponding to residues near the amino-terminus of human b-actin. |
Format: | Supernatant |
Database Information
KEGG ID : | K05692 | Matching products |
UniProt ID : | P60709 | Matching products |
Gene ID | GeneID 60 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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