Anti-ACE2 (human) (Clone AC384, preservative free)

Angiotensin-converting enzyme 2 (ACE2) is a carboxypeptidase and homolog of ACE1 that is encoded by ACE2 in humans. It is a type I transmembrane protein composed of a cytoplasmic tail and an extracellular domain containing an HEMGH motif, characteristic of zinc-metallopeptidases, which exhibits carboxymonopeptidase activity. ACE2 is expressed in vascular endothelial cells where it catalyzes the conversion of angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to the vasodilatory peptide angiotensin 1-7 to regulate systemic blood pressure. It is also expressed in the epithelial cells of the kidney, heart, lung, small intestine, and liver and has roles in fluid homeostasis, cardiac contractility, and amino acid absorption, as well as the prevention of pulmonary fibrosis and hypertension. ACE2 also acts as a functional receptor for severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 to facilitate viral entry into host cells. Cayman's ACE2 (human) Monoclonal Antibody (Clone AC384, preservative free) can be used for ELISA and Western blot (WB) applications.Synonyms: ACE-related Carboxypeptidase, ACEH, Angiotensin-converting Enzyme 2, Angiotensin-converting Enzyme Homolog, Metalloprotease MPROT15. Immunogen: Recombinant human ACE2. Clone Designation: AC384. Formulation: (Request formulation change), 100 or 500 µg of Protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.4. Host: Mouse. Isotype: IgG1. Applications: ELISA (direct or indirect), WB (using ECL).