- Macrolides
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Item number: Cay16486-5
Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is active against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s = 0.015-2.0 mg/l)....
Keywords: | NSC 55929, erythromycin |
Application: | Antibacterial macrolide antibiotic, Protein synthesis inhibitor (23S rRNA of 50S ribosomal subunit) |
CAS | 114-07-8 |
MW: | 733.9 D |
From 61.00€
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Item number: Cay19468-5
Nonactin, monactin, and dinactin mixture is a macrotetralide antibiotic. This product is a mixture of the macrotetralide antibiotic homologs nonactin, monactin (Cay-25742), and dinactin (Cay-20752) that all act as ionophores for monovalent cations. Nonactin is a mitochondrial membrane uncoupler and an inhibitor of...
Keywords: | (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octa... |
Application: | Macrotetrolide antibiotic, monovalent cation ionophore |
MW: | 736.9 D |
From 67.00€
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Item number: Cay20675-1
Azithromycin-d3 is intended for use as an internal standard for the quantification of azithromycin (Cay-15004) by GC- or LC-MS. Azithromycin is a macrolide antibiotic. It is active against S. pneumoniae, S. aureus, N. gonorrhoeae, M. pneumoniae, H. pylori, C. trachomatis, and H. influenzae in vitro (MIC90s = S....
Keywords: | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10... |
Application: | Internal standard, GC, LC-MS |
CAS | 163921-65-1 |
MW: | 752 D |
393.00€
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Item number: Cay22002-5
Lexithromycin is a semisynthetic antibiotic derived from erythromycin (Cay-16486). Lexithromycin has improved absorption in vivo over erythromycin due to increased hydrophopicity and pH stability. As with other macrolides, lexithromycin prevents protein synthesis by binding the ribosome at the polypeptide exit...
Keywords: | erythromycin, 9-(O-methyloxime) |
Application: | Antibiotic, Protein synthesis inhibitor |
CAS | 53066-26-5 |
MW: | 763 D |
From 234.00€
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Item number: Cay23879-5
Phanerosporic acid is a fungal secondary metabolite originally isolated from P. chrysosporum that has antibacterial activity against B. cereus, B. subtilis, and E. coli and antifungal activity against S. cerevisiae, A. niger, O. ulmi, U. maydis, C. cucmerinum, C. cladosporioides, and B. cinerea. It has been used in...
Keywords: | (-)-Phanerosporic Acid, 2,4-dihydroxy-6-[(14R)-14-hydroxypentadecyl]-benzoic acid |
Application: | Antibacterial, antifungal, building block |
CAS | 124709-28-0 |
MW: | 380.5 D |
From 330.00€
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Item number: Cay23642-5
Erythromycin A N-oxide is a potential impurity found in commercial preparations of erythromycin. Erythromycin (Cay-16486) is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is effective against a host...
Keywords: | erythromycin N-oxide |
Application: | Potential impurity |
CAS | 992-65-4 |
MW: | 749.9 D |
From 150.00€
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Item number: Cay18190-10
Tilmicosin is a macrolide antibiotic. It is active against macrolide-susceptible strains of M. haemolytica, P. multocida, and E. coli (MICs = 4, 4, and 128 µM, respectively), as well as a hyperpermeable strain of E. coli (MIC = 2 µM), and inhibits bacterial protein synthesis (IC50 = 0.36 µM). Tilmicosin (75 mg/kg)...
Keywords: | LY177370, Micotil,... |
Application: | 23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor, Macrolide antibiotic |
CAS | 137330-13-3 |
MW: | 967.1 D |
From 67.00€
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Item number: Cay19465-1
Roxithromycin is a macrolide antibiotic. It is active against various Gram-positive and Gram-negative bacteria, including five strains each of Staphylococcus and Streptococcus (geometric mean MICs = 0.08 and 0.79 µg/ml, respectively), as well as several strains each of Corynebacterium, Haemophilus, and S. pneumoniae...
Keywords: | RU 28965, RU 965, 9E-[O-[(2-methoxyethoxy)methyl]oxime]-erythromycin |
Application: | Antibiotic, 50S ribosomal subunit, protein synthesis inhibitor |
CAS | 80214-83-1 |
MW: | 837.1 D |
From 45.00€
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Item number: Cay24177-1
Leucomycin A5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimurium, or E. coli with MICs ranging from 5 to >10 µg/ml....
Keywords: | Kitasamycin A5, Leukomycin A5, Turimycin H4, 4B-butanoate leucomycin V |
Application: | Antibacterial |
CAS | 18361-45-0 |
MW: | 771.9 D |
From 243.00€
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Item number: Cay25310-1
Erythromycin-13C-d3 is intended for use as an internal standard for the quantification of erythromycin (Cay-16486) by GC- or LC-MS. Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is...
Keywords: | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahyd... |
Application: | GC-MS, LC-MS, NMR, internal standard |
CAS | 2378755-50-9 |
MW: | 738 D |
490.00€
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Item number: Cay15503-10
Fidaxomycin is a natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 µM, respectively). It has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile...
Keywords: | Clostomicin B1, Difimicin, Lipiarmycin, OPT-80, PAR-101, Tiacumicin B,... |
Application: | Macrolide-type antibiotic, Gram-positive bacteria RNA polymerase inhibitor |
CAS | 873857-62-6 |
MW: | 1058 D |
From 83.00€
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Item number: Cay23147-1
Nodusmicin is a macrolide antibiotic. It has activity against antibiotic-susceptible and -resistant S. aureus with MIC values of 125, 250, and 250 µg/ml for UC-76, UC-6685, and UC-6690 strains, respectively.Formal Name:...
Keywords: | (1E,3R,4S,7S,8aS,10aR,11R,12R,13R,14R,14aS,14bS)-3,4,8,8a,10a,11,12,13,14,14a-decahydro-12,14-dihydroxy-4-[(1R)-1-hydroxye... |
Application: | Macrolide antibiotic |
CAS | 76265-48-0 |
MW: | 422.5 D |
From 259.00€
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Item number: Cay15004-25
Azithromycin is a macrolide antibiotic. It is active against S. pneumoniae, S. aureus, N. gonorrhoeae, M. pneumoniae, H. pylori, C. trachomatis, and H. influenzae in vitro (MIC90s = S. pyogenes, S. pneumoniae, E. faecalis, or H. influenzae infection (ED50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively). It...
Keywords: | CP 62,993,... |
Application: | Antibiotic |
CAS | 83905-01-5 |
MW: | 749 D |
From 78.00€
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Item number: Cay15501-1
Chlorothricin is a macrolide-type antibiotic that inhibits pyruvate carboxylases from Bacillus, Azotobacter, rat, and chicken, preventing the conversion of pyruvate to oxaloacetate (Ki or IC50 = 173, 500, 260, and 120 µM, respectively). Chlorothricin also inhibits malate dehydrogenases MDH1 (cytoplasmic) and MDH2...
Keywords: | Antibiotic K 818A,... |
Application: | Macrolide-type antibiotic, Pyruvate carboxylase inhibitor |
CAS | 34707-92-1 |
MW: | 955.5 D |
From 209.00€
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Item number: Cay17089-1
Tildipirosin is a 16-membered macrolide used as an antibiotic in veterinary medicine. Like other macrolides, it inhibits protein synthesis in bacteria and blocks the production of biofilms. Tildipirosin is particularly effective against Gram-negative pathogens (MIC = 0.25-1 µg/ml against P. multocida and M....
Keywords: | 20-deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]-20,23-di-1-piperidinyl-tylonolide |
Application: | Bacterial protein synthesis inhibitor |
CAS | 328898-40-4 |
MW: | 734 D |
From 75.00€
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Item number: Cay17191-1
Erythromycin A enol ether is a decomposition product of the macrolide antibiotic, erythromycin A (Cay-16486). Erythromycin A enol ether does not retain the antibiotic properties of erythromycin A and has been identified as a beta-turn mimic of the peptide hormone motilin, causing duodenal contractions and...
Keywords: | BRL 46357ER, EM-201, 8,9-didehydro-9-deoxo-6-deoxy-6,9-epoxy-erythromycin |
Application: | Erythromycin A decomposition product, Peptide hormone motilin beta-turn mimic |
CAS | 33396-29-1 |
MW: | 715.9 D |
From 49.00€
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Item number: Cay20585-1
Leucomycin A1 is a major metabolite from the leucomycin complex, a family of macrolide antibiotics produced by S. kitasatoensis that are effective against Gram-positive bacteria, Gram-negative cocci, Leptospira, and mycoplasma. Leucomycin A1 is one of the more potent members of the complex.Formal Name: leucomycin V,...
Keywords: | 3-deacetyl Josamycin, 9-dihydro Niddamycin, Kitasamycin A1, Leucomycin V 4-isovalerate, Turimycin H5,... |
Application: | Macrolide antibiotic |
CAS | 16846-34-7 |
MW: | 786 D |
From 422.00€
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Item number: Cay21348-1
Davercin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 µg/ml). Davercin is non-toxic to mice...
Keywords: | Erythromycin cyclocarbonate, cyclic 11,12-carbonate erythromycin |
Application: | Semi-synthetic antibacterial macrolide antibiotic, protein synthesis inhibitor |
CAS | 55224-05-0 |
MW: | 759.9 D |
From 92.00€
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Item number: Cay15508-1
Pseudoerythromycin A enol ether is a degradation product of the macrolide antibiotic erythromycin (Cay-16486). It promotes monocyte differentiation into macrophages when used at a concentration of 10 µM.Formal Name:...
Keywords: | LY267108,... |
Application: | Erythromycin degradation product |
CAS | 105882-69-7 |
MW: | 715.9 D |
From 134.00€
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Item number: Cay19202-5
Tulathromycin A is a macrolide antibiotic that inhibits bacterial protein synthesis (IC50 = 0.26 µM) by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is effective against M. haemolytica and P. multocida (MICs = 2 and 0.5 µg/ml, respectively), which cause respiratory...
Keywords: | CP 472,295,... |
Application: | Bacterial protein synthesis inhibitor |
CAS | 217500-96-4 |
MW: | 806.1 D |
From 78.00€
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Item number: Cay20185-1
Oligomycin E is a minor metabolite of the oligomycin complex (Cay-11341) produced by several species of Streptomyces. It exhibits relatively weak antifungal activity compared to other oligomycins, yet is active against Gram-positive bacteria and demonstrates strong antitumor activity against HeLa cells (IC50 = 14...
Keywords: | 26-hydroxy-28-oxo-Oligomycin A,... |
Application: | Antibacterial (gram-positive), antitumor |
CAS | 110231-34-0 |
MW: | 821.1 D |
From 414.00€
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Item number: Cay20587-1
PC-766B is a macrolide antibiotic produced by N. brasiliensis that is active against Gram-positive bacteria and some fungi, yet inactive against Gram-negative bacteria. It also demonstrates antitumor activity against mouse P388 leukemia and B16 melanoma cells in vitro (IC50s = 0.1 and 0.4 ng/ml, respectively) and in...
Keywords: | Antibiotic PC-766B,... |
Application: | Macrolide antibiotic |
CAS | 108375-77-5 |
MW: | 777 D |
From 313.00€
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Item number: Cay22599-10
Tylosin is a macrolide antibiotic produced by S. fradiae that has bacteriostatic activity against Gram-positive bacteria. It is a mixture of tylosin A, B, C, and D, with tylosin A contributing 80% of its bacteriostatic activity. Tylosin has MIC values of 9.6, 16.4, 0.1, 1, and 0.5 µg/ml for F. necrophorum, A....
Keywords: | tylosin |
Application: | Macrolide bacteriostatic antibiotic |
CAS | 1401-69-0 |
MW: | 916.1 D |
From 61.00€
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Item number: Cay23389-10
Gamithromycin is an antibiotic that is active against macrolide-resistant R. equi and S. zooepidemicus (MIC90s = 1 and 0.125 µg/ml, respectively). It reduces the number of pneumonic lesions in a bovine M. haemolytica challenge model at a dose of 6 mg/kg. Formulations containing gamithromycin have been used to treat...
Keywords: | ML-1709460,... |
Application: | Antibiotic |
CAS | 145435-72-9 |
MW: | 777 D |
From 111.00€
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Item number: Cay19466-250
Dirithromycin is a macrolide antibiotic. It is a prodrug of erythromycylamine (Cay-28098) that has outstanding activity against Campylobacter. Dirithromycin is a group 3 agent with respect to its interaction with the cytochrome P450 (CYP) isoform 3A4, as it interferes poorly with CYP3A4 in vitro and generally does...
Keywords: | Antibiotic AS-E 136, LY237216,... |
Application: | Macrolide antibiotic, 50S ribosomal subunit protein synthesis inhibitor |
CAS | 62013-04-1 |
MW: | 835.1 D |
From 61.00€
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