Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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DOPAL
Item number: Cay18448-10
DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase. It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET, Cay-70604). DOPAL is toxic to neurons. It can also...
| Keywords: | 3,4-dihydroxy-benzeneacetaldehyde |
| Application: | Dopamine metabolite |
| CAS | 5707-55-1 |
| MW: | 152.1 D |
From 80.00€
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2'3'-cGAMP (sodium salt)
Item number: Cay19887-500
2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA. It contains a non-canonical 2'5'-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79...
| Keywords: | 2'-3'-Cyclic GMP-AMP, Guanosine-Adenosine 2',3'-cyclic monophosphate, adenylyl-(3'->5')-2'-guanylic acid, cyclic... |
| Application: | Second messenger |
| MW: | 718.4 D |
From 266.00€
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Mesembrine
Item number: Cay21100-5
Mesembrine is an alkaloid that has been found in S. tortuosum and has serotonin (5-HT) reuptake inhibitory activity. It selectively binds to the 5-HT transporter (SERT, IC50 = 4.3 µg/ml) over a variety of receptors (IC50s = 148->750 µg/ml). Mesembrine inhibits the reuptake of 5-HT in vitro (Ki = 1.4 nM). It has...
| Keywords: | (-)-Mesembrine, Mesembranone, (3aS,7aS)-3a-(3,4-dimethoxyphenyl)octahydro-1-methyl-6H-indol-6-one |
| Application: | Bioactive alkaloid, 5-HT reuptake inhibitor |
| CAS | 24880-43-1 |
| MW: | 289.4 D |
From 208.00€
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Protein Phosphatase 2A C subunit (human, recombinant,...
Item number: Cay10011237-10
Reversible protein phosphorylation is a fundamental regulatory mechanism in all aspects of biology. Protein phosphatase 2A (PP2A) is a divalent cation-independent protein serine/threonine phosphatase involved in regulating numerous cellular processes including the cell cycle, growth and differentiation and is also...
| Keywords: | RP-C, RP-C, PPP2CA, PP2A-alpha, PP2A-alpha, Replication protein C, Replication protein C, Serine/threonine-protein... |
| Application: | Enzyme activity |
| MW: | 38,6 kD |
385.00€
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13,14-dihydro-15-keto Prostaglandin F2alpha ELISA Kit
Item number: Cay516671-96
Prostaglandin F2alpha (PGF2alpha) is one of the five primary prostaglandins derived enzymatically directly from the endoperoxide PGH2. PGF2alpha was initially discovered in seminal fluid, and to date the majority of the functional roles ascribed to it relate to fertility, pregnancy, and parturition. PGF2alpha is a...
| Keywords: | 13,14-dihydro-15-keto PGF2alpha EIA Kit, PGFM EIA Kit |
| Application: | ELISA |
From 422.00€
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Cytochalasin B
Item number: Cay11328-10
Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis,...
| Keywords: | NSC 107658, Phomin,... |
| Application: | Mycotoxin |
| CAS | 14930-96-2 |
| MW: | 479.6 D |
From 60.00€
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Adenosine 5'-(gamma-thio)-triphosphate (lithium salt)
Item number: Cay14957-1
Adenosine 5'-(gamma-thio)-triphosphate (lithium salt) is a stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11). It has been used to identify kinase substrates, has been implemented as a reagent in the synthesis of DNA N-acetylglucosamine analogs,...
| Keywords: | ATPgammaS, P'-anhydride with phosphorothioic acid adenosine 5'-(trihydrogen diphosphate), tetralithium salt |
| Application: | ATP analog, GPCR P2Y2 / P2Y11 agonist |
| CAS | 93839-89-5 |
| MW: | 547 D |
From 42.00€
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DEA NONOate
Item number: Cay82100-10
DEA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2 minutes and 16 minutes at 37°C and 22-25°C, pH 7.4, respectively, to liberate 1.5 moles of NO per mole of parent compound.Formal Name: Diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate....
| Keywords: | DEA/NO, Diethylamine NONOate, Diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate |
| Application: | NO donor |
| CAS | 372965-00-9 |
| MW: | 206.3 D |
From 34.00€
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Tafluprost
Item number: Cay10005440-25
Tafluprost is a prodrug form of the FP receptor agonist tafluprost (free acid) (Cay-10005439) and a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020). It decreases pupillary diameter in cats when applied topically at doses of 0.0001 or 0.001% v/v. Ocular administration of tafluprost (0.0005% v/v)...
| Keywords: | AFP-168, 15,15-difluoro-9alpha,11alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl... |
| Application: | FP receptor agonist |
| CAS | 209860-87-7 |
| MW: | 452.5 D |
From 150.00€
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Kifunensine
Item number: Cay10009437-1
Kifunensine was originally isolated from the actinomycete Kitasatosporia kifunensine No. 9482 and shown to be a weak inhibitor of aryl mannosidase. It has since been shown to be a potent and selective inhibitor of class I alpha-mannosidases and may serve as a key inhibitor of glycoprotein biosynthesis. Kifunensine...
| Keywords: | FR900494, hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione |
| Application: | Alpha-mannosidase inhibitor |
| CAS | 109944-15-2 |
| MW: | 232.2 D |
From 88.00€
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(+)-JQ1
Item number: Cay11187-5
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. JQ1 displaces...
| Keywords: | (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid,... |
| Application: | BRD4 inhibitor |
| CAS | 1268524-70-4 |
| MW: | 457 D |
From 35.00€
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G-418 (sulfate)
Item number: Cay13200-5
G-418 is an aminoglycoside antibiotic. It is active against T. thermophila (IC50 = 10 µM). It inhibits the 80S ribosome and protein elongation during translation in a cell-free assay when used at a concentration of 2 nM. G-418 is used in molecular biology as a selective agent in cell lines or plasmids containing the...
| Keywords: | Geneticin,... |
| Application: | Antibiotic |
| CAS | 108321-42-2 |
| MW: | 692.7 D |
From 76.00€
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