Products from SYNkinase
SYNkinase, headquartered in Australia, is a primary producer of research-use-only biomedical reagents, which it markets to life-science and drug-discovery researchers affiliated with universities, research institutes and industry. SYNkinase was established in 2008 by Professor Andrew Wilks and Dr. Xian Bu. The founders of the company have been involved in pharmaceutical drug discovery for three decades and have extensive scientific, company and board experience.
More information at: www.adipogen.com/synkinase
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Ki-20227
Item number: SYN-1049-M001
Soluble in DMSO or ethanol. Ki20227 is a c-fms tyrosine kinase inhibitor. It has IC(50) values of 2, 12, 451 and 217nM for c-Fms, VEGFR-2, c-Kit and PDGFRbeta respectively. Target: c-fms , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | Ki-20227 |
| Application: | c-fms inhibitor |
| CAS | 623142-96-1 |
| MW: | 480,5 D |
From 132.00€
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Masatinib
Item number: SYN-1053-M001
Soluble in DMSO or ethanol.Masitinib is a potent, orally available protein tyrosine kinase inhibitor targeting c-Kit, PDGFR and FGFR3. It demonstrates activity for Kit and PDGFR alpha/beta with IC(50) values of 200nM, 540nM and 800nM respectively. It shows weak inhibition of ABL and c-Fms. Target: c-Kit, PDGFR and...
| Keywords: | AB1010, Masivet |
| Application: | c-Kit inhibitor |
| CAS | 790299-79-5 |
| MW: | 498,7 D |
From 59.00€
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PI103
Item number: SYN-1065-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PI-103 is an isoform-selective class I PI3K and mTOR inhibitor. It has activity on p110alpha-delta with IC(50) values of 2nM, 3nM, 3nM, 15nM respectively. It is less potent against mTOR and DNA-PK with IC(50) values of 30nM and 23nM respectively. Target: PI3K -...
| Keywords: | PI-103 |
| Application: | PI3K / DNA-PK / mTOR inhibitor |
| CAS | 371935-74-9 |
| MW: | 348,4 D |
From 125.00€
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GSK429286A
Item number: SYN-1071-M001
Soluble in DMSO. GSK429286A is a potent and selective inhibitor of Rho-associated kinase (ROCK1), with an IC(50) of 14nM. It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats. Target: ROCK , Kinase Group: AGC , Substrate: Serine-Threonine
| Keywords: | GSK-429286A, RHO-15 |
| Application: | ROCK inhibitor |
| CAS | 864082-47-3 |
| MW: | 432,4 D |
From 119.00€
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SB-242235
Item number: SYN-1076-M001
Soluble in DMSO. The p38 mitogen-activated protein kinase (MAPK) signaling pathway is activated by numerous inflammatory mediators and environmental stresses. SB-242235 is a potent and moderately selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or...
| Keywords: | SB-242235 |
| Application: | p38 inhibitor |
| CAS | 193746-75-7 |
| MW: | 353,4 D |
From 250.00€
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TG-89
Item number: SYN-1107-M001
Soluble in DMSO or ethanol. TG-89 is a JAK inhibitor. It has IC(50) values of 6, 25, 17 and 169nM against JAK2, FLT3, RET and JAK3 respectively. Target: JAK2 , Kinase Group: PTK , Substrate: Tyrosine
| Keywords: | TG89 |
| Application: | JAK2 / FLT3 / RET / JAK3 inhibitor |
| CAS | 936091-56-4 |
| MW: | 510,7 D |
From 250.00€
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GSK-25
Item number: SYN-1124-M001
Soluble in DMSO. GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC(50) of 398nM, p70S6K IC(50) of 1000nM), and a dramatically improved P450 profile (>2.2µM at all isozymes tested). Target: RSK1 - p70S6K , Kinase Group: AGC , Substrate: Serine-Threonine
| Keywords: | GSK-25 |
| Application: | RSK1 / p70S6K inhibitor |
| CAS | 874119-56-9 |
| MW: | 513,3 D |
From 250.00€
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Foretinib
Item number: SYN-1129-M001
Soluble in DMSO. Foretinib is a novel MET and VEGFR2 kinase inhibitor with IC(50) values of 0.4 and 0.8nM for MET and VEGFR2 respectively. Target: VEGFR2 - MET , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | GSK-1363089, EXEL-2880 |
| Application: | VEGFR2 / MET inhibitor |
| CAS | 849217-64-7 |
| MW: | 632,7 D |
From 139.00€
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NVP-BSK805
Item number: SYN-1136-M001
Soluble in DMSO or ethanol. NVP-BSK805 is a potent and selective quinoxaline JAK2 inhibitor with IC(50) values of 0.48, 0.56 and 0.58nM for JAK2 JH1, FL JAK (V617F) and FL JAK2 wt, respectively. Target: JAK2 , Kinase Group: PTK , Substrate: Tyrosine
| Keywords: | NVPBSK805 |
| Application: | JAK2 inhibitor |
| CAS | 1092499-93-8 |
| MW: | 563,5 D |
From 218.00€
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BMS-599626
Item number: SYN-1142-M001
Soluble in DMSO or ethanol. BMS-599626 is an orally bioavailable, highly selective and potent pan-HER kinase inhibitor. It inhibits HER1 and HER2 with IC(50) values of 20 and 30nM, respectively. Target: EGFR - HER2 , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | AC-480, BMS599626 |
| Application: | EGFR / HER2 inhibitor |
| CAS | 714971-09-2 |
| MW: | 530,6 D |
From 139.00€
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CH-5132799
Item number: SYN-1146-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. CH5132799 selectively inhibits class I PI3Kalpha with an IC(50) value of 14nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Keywords: | CH-5132799 |
| Application: | PI3K alpha inhibitor |
| CAS | 1007207-67-1 |
| MW: | 377,4 D |
From 165.00€
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RG-7422
Item number: SYN-1150-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC(50) values of 5, 27, 7, and 14nM for PI3Kalpha-delta respectively. It inhibits mTOR with a Ki of 17nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Keywords: | GDC-0980 |
| Application: | PI3K / mTOR inhibitor |
| CAS | 1032754-93-0 |
| MW: | 498,6 D |
From 132.00€
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