Description: Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects. Target: Transferase, NOD, NOD-like Receptor (NLR), Autophagy. Smiles: [H][C@@]12CC[C@]3(C)O[C@@]33CC=C(C)[C@]3([H])[C@@]1([H])OC(=O)C2=C....

White to off-white solid. Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water. Anticancer compound, Farnesyltransferase inhibitor, Potent anti-inflammatory agent, NF-kappaB inhibitor, Inflammasome inhibitor, Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.

Arglabin is a sesquiterpene gamma-lactone originally isolated from A. glabella that has anticancer and anti-inflammatory activities. It inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively). Arglabin reduces tumor growth in an SCC-4 mouse...