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Item number: Cay14269-5

Pemetrexed is an antifolate with anticancer activity. It is an inhibitor of folate-dependent enzymes involved in purine synthesis, including thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively, for the human recombinant enzymes), and the potency for thymidylate kinase is increased...

Keywords:	N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt,...
Application:	Antifolate
CAS	357166-29-1
MW:	597.5 D

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Pemetrexed, Disodium Salt, Heptahydrate...

Item number: P3148-07.250

Pemetrexed inhibits dihydrofolate reductase, thymidylate synthase and glycinamide ribonucleotide formyltransferase with Ki values of 7nM, 109nM and 9.3uM, respectively. Solubility: Very poorly soluble in DMSO and ethanol, soluble in water at 100mg/ml.. Buffers, serum, or other additives may increase or decrease the...

CAS	357166-29-1
MW:	597.48

245.00€ *

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