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Doramapimod
Item number: TGM-T6277-100mg
Description: Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70. Target: Autophagy, p38 MAPK, Raf. Smiles: Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C. References: Pargellis C, et al. Inhibition of p38...
| Keywords: | BIRB 796 |
| Application: | Targets p38 MAP kinase [EC:2.7.11.24] (P38) |
| CAS | 285983-48-4 |
| MW: | 527.66 D |
From 32.00€
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Doramapimod
Item number: Cay10460-1
The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFalpha release in...
| Keywords: | BIRB-796, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-urea |
| Application: | p38 MAPK inhibitor |
| CAS | 285983-48-4 |
| MW: | 527.7 D |
From 35.00€
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![Doramapimod, Free Base (1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy](https://www.biomol.com/media/image/e5/4c/a8/D9023-5_200x200.jpg "Doramapimod, Free Base (1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy")
Doramapimod, Free Base...
Item number: D9023.5
Doramapimod is a protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel...
| CAS | 285983-48-4 |
| MW: | 527.66 |
240.00€
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